Epithalon TFA

$216.00
In stock
SKU
W1506301-919-8
Epithalon TFA
Description
Epitalon TFA is an anti-aging agent and a telomerase activator. Epitalon TFA has an inhibitory effect of the on the development of spontaneous tumors in mice, has geroprotective actions and intranasal administration increases neuronal activity. Epitalon TFA can be used for cancer, old age and Retinitis Pigmentosa[1].
In Vitro
Addition of Epithalon peptide in telomerase-negative human fetal fibroblast culture induced expression of the catalytical subunit, enzymatic activity of telomerase, and telomere elongation, which can be due to reactivation of telomerase gene in somatic cells and indicates the possibility of prolonging life span of a cell population and of the whole organism[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Epitalon increases the lifespan of mice and fruit flies and restores the circadian rhythms of melatonin and cortisol production in old rhesus monkeys. At the same time, Epitalon prolongs the functional integrity of the eye retina in Campbell rats with hereditary Retinitis Pigmentosa and improves the visual functions in patients with pigmental retinal degeneration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight
504.37
Formula
C??H??F?N?O??
Sequence
Ala-Glu-Asp-Gly
Sequence Shortening
AEDG
Shipping
Room temperature in continental US; may vary elsewhere.
Storage
Stored under nitrogen

Powder
-80°C
2 years

-20°C
1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvent & SolubilityIn Vitro:


DMSO : 250 mg/mL (495.67 mM; Need ultrasonic)


Preparing
Stock Solutions



Concentration Solvent Mass

1 mg

5 mg

10 mg


1 mM1.9827 mL9.9134 mL19.8267 mL
5 mM0.3965 mL1.9827 mL3.9653 mL
10 mM0.1983 mL0.9913 mL1.9827 mL

*Please refer to the solubility information to select the appropriate solvent.

In Vivo:


1.


Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% saline

Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution


2.


Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution


3.


Add each solvent one by one: 10% DMSO 90% corn oil

Solubility: ≥ 2.08 mg/mL (4.12 mM); Clear solution


*All of the co-solvents are provided by MCE.
References
[1]. Khavinson VKh. et al. Peptides and Ageing. Neuro Endocrinol Lett. 2002;23 Suppl 3:11-144.

[2]. Vanhee C, et al. Identification of the small research tetra peptide Epitalon, assumed to be a potential treatment for cancer, old age and Retinitis Pigmentosa in two illegal pharmaceutical preparations. Drug Test Anal. 2015 Mar;7(3):259-64.

[3]. Khavinson VKh, et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003 Jun;135(6):590-2.
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